Stevens–Johnson syndrome with visceral arteritis due to sulphonylurea therapy

A 67‐year‐old male with recently diagnosed type 2 diabetes mellitus presented with clinical features characteristic of Stevens–Johnson syndrome and died from a haemorrhagic bronchopneumonia. Autopsy revealed features of granulomatous arteritis and an interface cholestatic hepatitis. The cause of these features was felt to be due to a hypersensitivity reaction to glibenclamide. Although unusual, drug hypersensitivity with sulphonylureas may be fatal. Copyright © 2004 John Wiley & Sons, Ltd.