‘No change for 5 years’ in diabetes pregnancy outcomes

The 2018 National Pregnancy in Diabetes audit has found a high level of stillbirth, neonatal death and congenital anomalies in pregnancies in women with pre-pregnancy diabetes (i.e. not gestational) compared with non-diabetic pregnancies (https://files.digital.nhs.uk/CF/4791D9/National%20Pregnancy%20in%20Diabetes%20Audit%20Report%202018.pdf). This finding, which has been similar for the past five years, …

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Plant-based diet lowers risk of type 2 diabetes

Following a plant-based diet could cut the risk of type 2 diabetes (T2D) by 20%, or by 30% if the diet is varied and healthy (JAMA Intern Med. 2019;179:1335-1344).
This meta-analysis of nine prospective observational studies assessing the relationship between adherence to plant-based dietary patterns and …

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Intranasal glucagon for severe hypoglycaemia

Baqsimi, a novel intranasal formulation of glucagon, has received a positive recommendation from the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) for the treatment of severe hypoglycaemia in adults and children over 4 years old. The decision requires endorsement by the …

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Employers can help weight loss

Removing access to sugary drinks at the workplace helps workers to lose weight, a US study has shown (JAMA Intern Med. Published online October 28, 2019. doi:10.1001/jamainternmed.2019.4434).
214 people who regularly consumed sugary drinks were monitored before and for 10 months after their employer (a university) …

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Toujeo for children soon

Toujeo 300 units/ml (insulin glargine) is soon likely to be licensed for the treatment of adolescents and children over 6 years old following a positive recommendation from the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP). It is currently licensed only for …

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New guidance on physical activity

Chief Medical Officers for the four Home Nations have published joint public health guidance on physical activity (https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/832868/uk-chief-medical-officers-physical-activity-guidelines.pdf).
The 66-page UK Chief Medical Officers’ Physical Activity Guidelines is intended for ‘health professionals, policymakers and others working to promote physical activity, sport and exercise for health benefits’. …

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European cardio guidelines updated

The European Society of Cardiology (ESC) and the European Association for the Study of Diabetes (EASD) have published updated joint guidelines on diabetes, pre-diabetes, and cardiovascular diseases. Available free online at https://academic.oup.com/eurheartj/advance-article-pdf/doi/10.1093/eurheartj/ehz486/29815307/ehz486.pdf, this is the third version of advice on the management and prevention of …

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Cloud integration for insulin monitoring and delivery

Abbott and Sanofi have announced a strategic partnership that will see the integration of cloud data and mobile apps currently dedicated separately to the FreeStyle Libre glucose monitoring system and Sanofi’s emerging data management software for its insulin pens and dose titration software.
The first step …

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Degludec vs glargine U300

Insulin degludec is associated with ‘an overall lower risk of hypoglycaemia… at a significantly lower HbA1c, compared with insulin glargine U300 in adults with type 2 diabetes uncontrolled on basal insulin with or without oral anti-diabetic drugs’, according to data from the CONCLUDE trial presented …

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Early combination therapy for type 2 diabetes

‘Early intervention with a combination therapy of vildagliptin plus metformin provides greater and durable long-term benefits compared with the current standard-of-care initial metformin monotherapy for patients with newly diagnosed type 2 diabetes’, according to the results of the 5-year VERITY study presented at the European …

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